The ancient port city of Antioch in Syria (modern Samandag, Turkey), founded by Seleucus I Nicator in 301 BCE. According to (Acts 13:4), Barnabas and Paul, accompanied by John Mark, sailed from Seleucia to Cyprus at the beginning of their first missionary journey (ca. 49 CE). Other references to voyages to and from Antioch probably imply embarkation and landing at Seleucia (Acts 14:26; Acts 15:39). Other cities also named Seleucia were in Cilicia, Mesopotamia, and Bashan.
The Apostles Preach in Cyprus
4So, being sent out by the Holy Spirit, they went down to Seleucia; and from there they sailed to Cyprus.
26From there they sailed back to Antioch, where they had been commended to the grace of God for the work that they had completed.
39The disagreement became so sharp that they parted company; Barnabas took Mark with him and sailed away to Cyprus.